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KMID : 0043320080310030399
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Archives of Pharmacal Research
2008 Volume.31 No. 3 p.399 ~ p.405
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Paroxetine Hydrochloride Controlled Release Matrix Tablets: Screening of Formulation Variables using Plackett-Burman Screening Design
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Jin Shun-Ji
Yoo Yeon-Hee
Kim Min-Soo
Kim Jeong-Soo
Park Jeong-Sook
Hwang Sung-Joo
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Abstract
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The aim of the present study was to screen the effects of the formulation variables - molecular weight , the ratio of / PH102 and the amount of and PH102 , hardness , HPMCP amount , L100 amount , and citric acid amount - on the paroxetine hydrochloride release from matrix tablet using the Plackett-Burman screening design. Paroxetine hydrochloride matrix tablets were prepared according to a 7-factor-12-run statistical model and subjected to a 8-h dissolution study in Tris buffer at pH 7.5. The regression results showed that molecular weight and / PH102 ratio had significantly influence on the drug release mechanism and drug release rate as main effects. Hardness had an insignificant effect on the drug release mechanism but a significant effect on the drug release rate. On the other hand, HPMCP, L100 and citric acid had an insignificant effect on the both responses. The information obtained by screening design study can be expected to be useful for further formulation studies.
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KEYWORD
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Paroxetine hydrochloride, Plackett-Burman screening design, Controlled release
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